Example is the increased absorption and bioavailability of. Show all medications in the database that may interact with captopril. Effects of food on absorption effects of food on metabolism. From the safety viewpoint, the pharmacist has the legal duty to warn about potentially harmful drug interactions. Most people get enough vitamin d from exposure to the sun and from fortified food products e. Captopril is used to treat high blood pressure hypertension. Drug information table ace inhibitors captopril capoten. Bananas, green leafy vegetables, oranges, salt substitutes. It is also used to treat heart failure, protect the kidneys from harm due to diabetes, and to improve survival after a heart attack. Excessive hypotension may occur with concurrent use of diuretics. Aspirin digoxin antihypertensive agents drugs that increase potassium levels diuretics.
There are 19 disease interactions with captopril hydrochlorothiazide which include. Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. Ace inhibitors such as captopril capoten, enalapril vasotec, and lisinopril prinivil. For instance, absorption of captopril decreases significantly if it is not taken with an empty stomach. Captopril has the capacity to increase potassium level in the blood.
Learn about the most common food and drug interactions below. Serious, potentially fatal adverse reactions may occur with. There are 4 alcoholfoodlifestyle interactions with captopril hydrochlorothiazide which include. In this scenario, i will discuss the lithium and ace inhibitor drug interaction. Focus on drugfood interactions memorize lists of interactions poor clinical relevance. Actually, drugnutrient interactions are some of many possible fooddrug interactions. It was also found that the total interactions between foodnutrients and drugs, 32 53% accounted. Dairy products, such as milk, yogurt, and cheese, can interfere with the absorption of antibiotics into the bloodstream. This can lead to unwanted side effects, toxic levels of a drug in the body, or little to no effect of the drug.
Drugfood interactions 2 nutritional supplements and. The lithium and ace inhibitor drug interaction is a significant one in my opinion. Interactions affecting drug absorption springerlink. Interactions between drugs and drugnutrient in enteral. Since the bioavailability and clinical effect of most drugs are correlated, the bioavailability is an important pharmacokinetic effect parameter. Diltizem,verapamil, and amlodipine have no significant interactions with grapefruit juice. Just as one drug may interact with another, drugs may also interact with nutrients. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Captopril interactions with food and herbs potassium rich foods. Interactions between food and drugs may inadvertently reduce or increase the drug effect. Ace inhibitors captopril capoten therapeutic use administration treatment of hypertension heart failure hf diabetic nephropathy left ventricular dysfunction following myocardial infarction, ramipril available for oral use only must be taken two to three times daily for hypertension. Drugs and nutrients share similar characteristics, including sites of absorption in the intestine, the ability to alter physiological processes and the capacity to cause toxicity at high doses. This means providing safe, effective, timely, and costconscious therapy.
Moderate captopril alcohol ethanol moderate drug interaction. A total of 354 drugs are known to interact with captopril. Reducing your risk of adverse medication interactions. Lee vermeulen, ms, rph, director, center for drug policy, university of wisconsin hospital and clinics sarah bland is a clinical pharmacist in the center for drug policy and clinical economics, department of pharmacy, university of wisconsin hospital and clinics, and is a.
Chemical basis of drug action pha337 and pha447 is a required 2semester course sequence taught to secondprofessional year pharmacy students at creighton university in both the campus and distanceeducation pathways. Drugnutrient interactions involve changes to a drug caused by a nutrient, or changes to a nutrient as a result of the drug. Drugfood interaction occurs when the food you eat reduces the drugs efficacy. Captopril definition of captopril by medical dictionary. Not all drug interactions will be covered, and drugherbal5,6 and drugnutrient6,7 interaction information can be found elsewhere, as well as nondiabetesrelated drugdrug. A drug interaction is a situation in which a substance usually another drug affects the activity of a drug when both are administered together. Based on the results of the study, the most fooddrug interactions was respectively with drugs captopril, metoral and the heparin. What are drugdrug interactions of captopril enalapril. Captopril is a white to offwhite crystalline powder that may have a slight sulfurous odor. High levels of potassium can lead to irregular heartbeat. Journal of chemical and pharmaceutical sciences issn. A drug is defined as a substance used in the diagnosis, treatment, or prevention of a disease, or component of a medication.
Food can interact with certain drugs by either causing too much or too little of the drug to exert its effect in the body. Although captopril and hydrochlorothiazide are frequently combined together, their effects may be additive on lowering your blood pressure. Assessment of drug interactions in elderly patients of a. The mission of pharmacy practice is to help patients make the best use of their medication. The course emphasizes integration of previous content, critical thinking, and therapeutic relevance.
Hypertensive crisis may occur with ingestion of foods containing high concentrations of tyramine. Captopril hydrochlorothiazide disease interactions. Drug interactions of medications commonly used in diabetes. Drugdrug interactions can be classified in terms of indirect effects by one drug on gastrointestinal tract physiology influencing the absorption of other drugs, or direct interactions involving altered ph, adsorption, absorption, or chelation. There are 564 drug interactions with captopril hydrochlorothiazide. Drugfood interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Drugfood interactions are important for two ace inhibitors, moexipril and captopril, which should be administered 1 hour before or at least 2 hours after a meal. Route onset peak duration captopril toepril po 1560min. How should we proceed and which medication would you select. The majority of clinically relevant fooddrug interactions are caused by foodinduced changes in the bioavailability of the drug. Specific fooddrug effects it is primarily in two realms pharmacokinetics, and pharmacotherapeutics where we can have fooddrug interactions the interactions can be.
Although it is well known and identifi ed that drugdrug interactions exist, the recognition of importance of food and drug interactions to practice has been growing much slower. There are 8 disease interactions with captopril which include. The drugs within their same pharmacological class can differ in their possibilities for drug food interactions. What are drugfood considerations when taking captopril enalapril.
Fooddrug interactions is a broader term that describes the effects of a drug on nutritional status. Potential drugdrug interactions with higher incidence according to reports of the elderly assisted by a family health care unit, in aracaju, brazil, 2008. Published articles from january 1990 to april 20 with the following study designs were selected. Definition of termsdefinition of terms drugnutrient interaction. The complex interaction between food, nutrients, and drugs, make it difficult to accurately determine the exact effects of these relationships in the body. Dont learn the hard way which foods can prevent a prescription or overthecounter drug from working, or exacerbate. Type in a drug name to check for interactions with captopril. Interactions between antihypertensive drugs and food. Each of these interactions may lead to many complications.
They are localized in organs such as small intestine, liver, and kidney, which are critical for drug absorption and elimination. Moreover, they can be found in important bloodtissue barriers such as the bloodbrain barrier. There are many dramatic results and problems that may be caused by fooddrug. The role of clinical pharmacists in educating nurses to. Captopril is an angiotensinconvertingenzyme inhibitor ace inhibitor and increase serum potassium value by reduction the activity of the reninangiotensinaldosterone molnar, 2014. Drugfood interactions occur when a drug interacts with something you eat or drink. Analysis of possible foodnutrient and drug interactions. A 48 year old male with a history of bipolar disorder has been recently diagnosed with hypertension. Generally, the effect of food on drugs results in a reduction in the drugs bioavailability. Lithium and ace inhibitor drug interaction med ed 101.